progeny – Communicable Diseases Research

Production of single-cycle infectious SARS-CoV-2 through a trans-complemented replicon

Article

Published on 2022-12-012022-11-16
Journal: Journal of medical virology
[Category] COVID19(2023년), SARS, 치료기술,

Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds

양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants
[DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article

The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness

Article

Published on 2022-09-132022-11-16
Journal: Scientific Reports
[Category] SARS, 변종,

Unique mutations in SARS-CoV-2 Omicron subvariants’ non-spike proteins: Potential impacts on viral pathogenesis and host immune evasion

Article

Published on 2022-09-012022-11-16
Journal: Microbial pathogenesis
[Category] SARS, 변종,

[키워드] Accessory accessory proteins B.1.1.7 B.1.617.2 Beta Cell Characteristics circulating COVID-19 pandemic cumulative Delta dominant Effect effective element epistasis expression FIVE Gamma growth Host host protein immune evasion immune-evasion Impact inactivation Interaction knowledge M protein Mutation mutations natural killer Non-spike mutations non-structural protein NSP6 omicron ORF7b Orf9b outcome P.1 Potential Probability progeny Protein Proteins Region Replication responsible SARS-CoV-2 significant difference Subvariants survival transmission rate unique variant variants of concern variants of concern. variants of interest viral pathogenesis virulence virus VOCs
[DOI] 10.1016/j.micpath.2022.105699 PMC 바로가기

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

SARS-CoV-2에 의한 폐 감염은 심각한 COVID-19에서 염증성 표현형과 함께 노화를 유도합니다: 바이러스 돌연변이 유발 가능성

Article

Published on 2022-08-182022-09-11
Journal: The European Respiratory Journal
[Category] Fulltext, SARS, 진단, 치료기술,

[키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus alveolar analysed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 APOBEC Apolipoprotein B AT2 Cell cells cellular senescence chronic inflammation Comorbidity Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL8 cytokine Cytokines demonstrated disease DNA damage electron microscopy enzyme Enzymes epithelial exhibited expressed expression extrapulmonary sites H2Ax IL-1β IL-6 IL-6 expression immunocytochemistry immunohistochemistry implication in vitro induce infecting Infection Inflammation inflammatory phenotype Inflammatory response investigated kidney liver lung tissue sample marker Microscopy molecular mechanism multisystemic disease Mutagenesis Non-COVID-19 persistence phenotype progeny proinflammatory promote pulmonary respiratory Respiratory system SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutagenesis SARS-CoV-2 mutations SARS-CoV-2 strain SARS-CoV-2 strains SASP senescence senescent cell Sequencing analysis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 Strains Vero-E6 cell Vero-E6 cells Viral mutagenesis
[DOI] 10.1183/13993003.02951-2021 PMC 바로가기 [Article Type] Article

The Cyclophilin-Dependent Calcineurin Inhibitor Voclosporin Inhibits SARS-CoV-2 Replication in Cell Culture

사이클로필린 의존성 칼시뉴린 억제제 보클로스포린은 세포 배양에서 SARS-CoV-2 복제를 억제합니다

Article

Published on 2022-06-242022-09-11
Journal: Transplant International
[Category] COVID19(2023년), SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity Antiviral assays assays benefit binding calcineurin calcineurin inhibitors can not clinical evaluation CNI Combination Comorbidity Compound compounds Concentration coronavirus Coronaviruses Course COVID-19 cyclophilin cyclosporin cyclosporin A EC50 value EC50 values evaluated experiments False-positive results human Calu-3 cell human Calu-3 cells Immunosuppressant immunosuppressants Immunosuppression immunosuppressive increased risk Infection inhibitor Interference kidney kidney transplant recipients Kidney transplantation lab progeny protocol recipient reduced reducing regimen reported RNA viruses SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus tacrolimus voclosporin voclosporin. with COVID-19
[DOI] 10.3389/ti.2022.10369 PMC 바로가기 [Article Type] Article

The life cycle and enigmatic egress of coronaviruses

코로나바이러스의 수명 주기와 불가사의한 탈출

Review

Published on 2022-06-012022-09-11
Journal: Molecular microbiology
[Category] COVID19(2023년), SARS, 치료법,

[키워드] adopted alternative route causative agent Cell cell surface cellular Consensus coronavirus CoV CoV infection CoV replication COVID-19 pandemic CoVs drugs Endoplasmic reticulum expression Extracellular genome replication genomic RNA Golgi Golgi apparatus host cell host cells Interference life cycle lumen membrane envelope mobilization nucleocapsid nucleocapsid protein Nucleocapsid proteins pandemic pathway progeny promote Protein rab1 rab11 respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown situation the Golgi apparatus the intermediate compartment (IC) the recycling endosome (RE). therapeutic virion assembly virus virus
[DOI] 10.1111/mmi.14907 PMC 바로가기 [Article Type] Review

Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In Vivo

Molnupiravir 및 활성 형태인 EIDD-1931, 시험관 내 및 생체 내 엔테로바이러스 감염에 대한 강력한 항바이러스 활성을 나타냄

Article

Published on 2022-05-252022-09-11
Journal: Viruses
[Category] 치료제,

Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis

세포내 및 형태학적 분석을 통한 SARS-CoV-2에 대한 플리티뎁신의 항바이러스 활성 규명

Article

Published on 2022-04-012022-09-11
Journal: Antiviral Research
[Category] Coronavirus, COVID19(2023년), SARS, 치료기술, 치료법, 치료제,

[키워드] absence Affect Alpha Analysis antitumor agent Antiviral antiviral activity antiviral drugs Antiviral treatment approach biogenesis block caused Cell Complete coronavirus COVID-19 double-stranded RNA dsRNA Efficacy electron electron microscopy elongation factor eukaryotic translation evaluate the effect Extracellular genome replication group host protein infected Vero E6 cells Interaction labeling mechanism mechanism of action Microscopy morphogenesis Morphological morphological analysis New coronavirus new coronavirus SARS-CoV-2 offer organelle pandemic plasma membrane Plitidepsin Post-infection progeny Protein provided SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2. shown Structure subcellular Support target TEM transmission electron microscopy treated unique Vero E6 Vero E6 cell VERO E6 cells Vesicle viral infection Viral particles viral replication virion virus virus viruses
[DOI] 10.1016/j.antiviral.2022.105270 PMC 바로가기 [Article Type] Article

Sensitivity of SARS-CoV-2 Life Cycle to IFN Effects and ACE2 Binding Unveiled with a Stochastic Model

Article

Published on 2022-02-152022-10-28
Journal: Viruses
[Category] COVID-19, COVID19(2023년), Fulltext, SARS,